Compare to the active ingredients in Imodium Multi-Symptom Relief. Don’t let symptoms of diarrhea plus cramps and pressure, bloating and gas derail your day. Up&Up Loperamide Hydrochloride and Simethicone Caplets, 2 mg/125 mg (capsule-shaped tablets) provides two medications for multi-symptom relief for adults and children ages 6 years and older. Active ingredients are loperamide hydrochloride 2 mg, anti-diarrheal, and simethicone 125 mg, anti-gas. Here's your multi-symptom medication choice when diarrhea, cramps and pressure, bloating and gas interfere with daily activities. This product is gluten free. Keep on hand at home and while on the go.