Compare to Vicks NyQuil Severe Cold and Flu active ingredients. Up&Up Nighttime Severe Cold and Flu Relief provides maximum strength relief for common cold and flu-like symptoms so you can rest. One dose relieves headache, fever, sore throat, minor aches and pains, sinus congestion and pressure, sneezing, runny nose and cough. Contains Acetaminophen (pain reliever/fever reducer); Dextromethorphan HBr (cough suppressant); Doxylamine Succinate (antihistamine); and Phenylephrine HCl (nasal decongestant). Get maximum strength, multi-symptom relief so you can sleep. In mixed berry flavor, for adults and children 12 years and older. This product is alcohol free, sugar free and gluten free.